Olivier Giroud returns from his ban, but Rafael Leao is still out with a decimated defence as Milan face an Atalanta side in crisis including Charles De Ketelaere.
It kicks off at the Gewiss Stadium in Bergamo at 17.00 GMT.
This is a head-to-head for the top four and both teams have struggled this season, although the Rossoneri are getting back on track with two straight wins.
Giroud is available after a two-match Serie A ban, but Rafael Leao is not ready yet and hopes to make his comeback against Newcastle United.
Noah Okafor, Simon Kjaer, Malick Thiaw, Pierre Kalulu, Marco Sportiello, Mattia Caldara and Marco Pellegrino are all injured too, so Theo Hernandez is again a makeshift central defender.
Atalanta have a few issues too, missing Gianluca Scamacca, El Bilal Toure, Rafael Toloi and Jose Luis Palomino, with Berat Djimsiti not at 100 per cent.
It means De Ketelaere starts against his parent club with Ademola Lookman and Teun Koopmeiners.
La Dea are through to the Europa League next phase as group winners, but managed only one point from the last four Serie A rounds, coming off a humiliating 3-0 defeat to Torino.
Atalanta: Musso; De Roon, Scalvini, Djimsiti; Ruggeri, Ederson, Pasalic, Zappacosta; Koopmeiners; Lookman, De Ketelaere
Milan: Maignan; Calabria, Tomori, Theo Hernandez, Florenzi; Loftus-Cheek, Musah, Reijnders; Chukwueze, Giroud, Pulisic
Player statistic
| Ademola Lookman (Assist: Teun Koopmeiners) |
 |
38' | ||
| 45+3' | |
Olivier Giroud (Assist: Alessandro Florenzi) |
| Ademola Lookman (Assist: Charles De Ketelaere) |
|
55' | ||
| 71' |  |
Tijjani Reijnders | ||
| Éderson | |
72' | ||
| 80' | |
Luka Jovic (Assist: Christian Pulisic) | ||
| 81' | |
Davide Calabria | ||
| 88' | |
Luka Jovic | ||
| Luis Muriel (Assist: Aleksey Miranchuk) |
|
90+5' | ||
| 90+2' | |
Ismaël Bennacer | ||
| 90+3' |  |
Davide Calabria |
Match statistic
