Ademola Lookman and Rasmus Højlund start in attack for Atalanta, while Lecce’s Marco Baroni looks to Assan Ceesay and Lameck Banda.
It kicks off at 11.30 GMT.
Giorgio Scalvini and Marten De Roon are suspended, while Hans Hateboer, Mario Pasalic and Duvan Zapata are injured.
Atalanta are unbeaten in 11 of their 12 home games against Lecce and the Giallorossi’s only win in Bergamo was in 1994.
Only Napoli have earned more points than Atalanta in 2023, but La Dea is the team with the most goals in the new year, 19, 2.7 per game on average.
Samuel Umtiti, Kastriot Dermaku and Marin Pongracic are injured. Gabriel Strezza has had flu, but is available, while Joan Gonzalez is suspended.
Lecce won the reverse fixture and haven’t won two games in one season against La Dea since 1993-94.
They have conceded 25 goals so far, which is a record for the club in Serie A. Lecce had always conceded at least 26 goals after the opening 22 games in Italy’s top flight.
Atalanta vs. Lecce – confirmed line-ups
Atalanta (3-4-1-2): Musso; Toloi, Palomino, Djimsiti; Maehle, Ederson, Koopmeiners, Maehle; Boga; Lookman, Hojlund.
Lecce (4-3-3): Falcone; Gendrey, Baschirotto, Ceccaroni, Gallo; Maleh, Hjulmand, Blin; Banda, Ceesay, Di Francesco.