Lazio use Felipe Anderson as a False 9 to replace injured Ciro Immobile, while Atalanta hope to continue their unbeaten record with Ademola Lookman and Luis Muriel.
It kicks off at the Gewiss Stadium at 17.00 UK time (16.00 GMT).
La Dea are still unbeaten this season and can temporarily go top of the table with a victory, awaiting tonight’s Roma-Napoli showdown.
The injury crisis is also beginning to ease, with only Rafael Toloi, Davide Zappacosta and suspended Jose Luis Palomino still absent.
Juan Musso returns to the bench over a month after fracturing his cheekbone and Duvan Zapata is also back in the squad, but Lookman and Muriel continue to lead the attack.
Lazio are forced to face life without hitman Immobile, who suffered a thigh strain last week, so Felipe Anderson is chosen as the False 9 in his place, flanked by Pedro and Mattia Zaccagni.
Atalanta: Sportiello; Okoli, Demiral, Scalvini; Hateboer, De Roon, Koopmeiners, Soppy; Pasalic; Lookman, Muriel
Lazio: Provedel; Lazzari, Casale, Romagnoli, Marusic; Milinkovic-Savic, Cataldi, Vecino; Pedro, Felipe Anderson, Zaccagni