Atalanta go with Ademola Lookman and Duvan Zapata against Inter’s Lautaro Martinez and Edin Dzeko in a fascinating head-to-head for Champions League places.
It kicks off at the Gewiss Stadium in Bergamo at 11.30 GMT.
This is a Lombardy Derby and both sides are stuck together on 27 points in joint fifth place, so a win either way could be the launchpad they need going into the second part of the season in January.
La Dea suffered a shock midweek defeat to Lecce as they rotated the squad, but the big guns are back, except for injured Luis Muriel, Marten de Roon and Davide Zappacosta.
Duvan Zapata leads the way with support from on-form Ademola Lookman, Mario Pasalic and Teun Koopmeiners.
Inter are missing Romelu Lukaku, Matteo Darmian and Danilo D’Ambrosio, but after losing to Juventus, restored some confidence by crushing Bologna 6-1.
The Nerazzurri have so far failed to win a single clash with one of the other big clubs this season.
Lautaro Martinez and Dzeko start upfront with Henrikh Mkhitaryan and Hakan Calhanoglu in midfield, as Marcelo Brozovic is still not ready for 90 minutes.
Atalanta have not beaten Inter since a 4-1 result in November 2018, followed by five draws and two defeats.
Atalanta: Musso; Toloi, Demiral, Scalvini; Hateboer, Pasalic, Koopmeiners, Maehle; Ederson; Lookman, Duvan Zapata
Inter: Onana; Skriniar, De Vrij, Bastoni; Dumfries, Barella, Calhanoglu, Mkhitaryan, Dimarco; Lautaro Martinez, Dzeko