It kicks off at the Gewiss Stadium in Bergamo at 17.30 UK time (16.30 GMT).
You can follow all the build-up and action as it happens from today’s four Serie A games on the LIVEBLOG.
La Dea opened their campaign with a hard-fought and barely-deserved 2-1 win away to Torino, so need to step up a gear in front of the home fans.
Remo Freuler and Rafael Toloi return, with Marten de Roon still suspended, Duvan Zapata and Hans Hateboer injured.
Bologna are never dull, losing 5-4 to Ternana in the Coppa Italia and beating Salernitana 3-2 in Serie A.
Jerdy Schouten and Roberto Soriano sit out bans after red cards in that match, so Matias Svanberg steps in behind Arnautovic.
Atalanta: Musso; Toloi, Palomino, Djimsiti; Maehle, Freuler, Pasalic, Gosens; Malinovskyi; Ilicic, Muriel
Bologna: Skorupski; De Silvestri, Medel, Bonifazi, Hickey; Kingsley, Dominguez; Orsolini, Svanberg, Sansone; Arnautovic