Atalanta hope to make the most of Bologna’s leaky defence with Luis Muriel and Josip Ilicic, but also have to watch out for Marko Arnautovic.
It kicks off at the Gewiss Stadium in Bergamo at 17.30 UK time (16.30 GMT).
You can follow all the build-up and action as it happens from today’s four Serie A games on the LIVEBLOG.
La Dea opened their campaign with a hard-fought and barely-deserved 2-1 win away to Torino, so need to step up a gear in front of the home fans.
Remo Freuler and Rafael Toloi return, with Marten de Roon still suspended, Duvan Zapata and Hans Hateboer injured.
Bologna are never dull, losing 5-4 to Ternana in the Coppa Italia and beating Salernitana 3-2 in Serie A.
Jerdy Schouten and Roberto Soriano sit out bans after red cards in that match, so Matias Svanberg steps in behind Arnautovic.
Atalanta: Musso; Toloi, Palomino, Djimsiti; Maehle, Freuler, Pasalic, Gosens; Malinovskyi; Ilicic, Muriel
Bologna: Skorupski; De Silvestri, Medel, Bonifazi, Hickey; Kingsley, Dominguez; Orsolini, Svanberg, Sansone; Arnautovic