Atalanta look to Charles De Ketelaere and Ademola Lookman, while Bologna have Joshua Zirkzee and Riccardo Orsolini in this head-to-head for Champions League football.
It kicks off at the Gewiss Stadium in Bergamo at 17.00 GMT.
This is a real showdown for fourth place, as only two points separate the teams, and Roma’s win away to Monza last night allowed the Giallorossi to nestle between them.
In theory, fifth place could be enough for qualification to the expanded Champions League, so this race is going down to the wire.
This also represents a showdown between maestro and pupil, as Thiago Motta was Gian Piero Gasperini’s player at Genoa.
Atalanta are still smarting from the rescheduled midweek 4-0 defeat to Inter, but have a full squad to choose from, including the first start for Lookman since Africa Cup of Nations duty with Nigeria.
He is accompanied by De Ketelaere and Teun Koopmeiners, leaving Gianluca Scamacca on the bench.
Until the loss to Inter, La Dea had put together four straight wins and a draw away to Milan.
Bologna are on stunning form with five consecutive Serie A victories in which they scored 14 goals and conceded three.
Adama Soumaoro remains the only injury absentee, as Alexis Saelemaekers shakes off a knock for a spot on the bench.
Zirkzee leads the attack with support from Orsolini, Giovanni Fabbian, Dan Ndoye and Lewis Ferguson.
When these sides met in December, Bologna emerged 1-0 winners thanks to a late Ferguson header and it’s worth remembering, because if two teams finish level on points, they are separated by head-to-head record.
Atalanta: Carnesecchi; Scalvini, Djimsiti, Kolasinac; Zappacosta, De Roon, Pasalic, Ruggeri; Koopmeiners; De Ketelaere, Lookman
Bologna: Skorupski; Posch, Beukema, Calafiori, Kristiansen; Freuler, Fabbian, Ferguson; Orsolini, Zirkzee, Ndoye
Player statistic
6' | Stefan Posch | |||
Teun Koopmeiners | 14' | |||
Ademola Lookman | 28' |
57' | Joshua Zirkzee | |||
61' | Lewis Ferguson | |||
Emil Holm | 64' | |||
Éderson | 69' | |||
90+4' | Jens Odgaard |