Check the official line-ups for the early games, as Atalanta-Torino can be decisive for Europe, while Napoli host Lecce.
Both Serie A Week 38 ties kick off at 17.00 UK time (16.00 GMT).
La Dea will show off the Europa League trophy to the crowd at the Gewiss Stadium and hope to finish higher than fifth in Serie A.
However, if they do that, then Roma cannot get an extra Champions League slot, as it only applies if Atalanta are fifth.
It’s also not the last game of the season for them, as their rescheduled encounter with Fiorentina is on June 2, called off on March 17 when Viola director Joe Barone died.
Torino and Napoli still have hope too, as if Fiorentina win the Conference League and therefore qualify for the Europa League, then ninth place will be worth Conference League entry.
Torino are currently ninth on 53 points, followed by Napoli on 52.
Atalanta-Torino
Atalanta: Carnesecchi; Toloi, Djimsiti, Scalvini; Holm, Koopmeiners, Pasalic, Zappacosta; Lookman, Scamacca, De Ketelaere
Torino: Gemello; Tameze, Buongiorno, Masina; Bellanova, Linetty, Ilic, Vojvoda; Ricci, Pellegri; Duvan Zapata
Napoli-Lecce
Napoli: Meret; Di Lorenzo, Ostigard, Juan Jesus, Olivera; Anguissa, Lobotka, Cajuste; Politano, Simeone, Kvaratskhelia
Lecce: Falcone; Gendrey, Baschirotto, Pongracic, Gallo; Ramadani, Berisha; Almqvist, Blin, Dorgu; Krstovic