A battle in the south sees Serie A strugglers Lecce host league leaders Napoli, who are hungry to bounce back after their shock defeat to Milan.
The match between the Salentini and the Partenopei kicks off at 18:00 UK time at the Stadio Via del Mare in Lecce.
Napoli have looked borderline unstoppable this season but were left stunned last weekend as Stefano Pioli’s Milan flew to a 4-0 win at the Stadio Diego Armando Maradona.
The Partenopei are hungry to take revenge on the Rossoneri but first need to rediscover some momentum against Lecce, with Luciano Spalletti expecting a strong response.
When these two teams met back in August, Napoli were held to a 1-1 draw at home.
Napoli are without star striker Victor Osimhen, who is dealing with a muscle issue.
Kastriot Dermaku and Marin Pongracic are both unavailable for Lecce through injury, and Alexis Blin is out due to a suspension.
Probable line-ups for Lecce vs Napoli
Lecce (4-3-3): Falcone; Gendrey, Baschirotto, Umtiti, Pezzella; Gonzalez, Hjulmand, Maleh; Strefezza, Ceesay, Di Francesco.
Napoli (4-3-3): Meret; Di Lorenzo, Kim, Juan Jesus, Mario Rui; Zambo Anguissa, Lobotka, Elmas; Lozano, Simeone, Kvaratskhelia.