Lazio will be looking to continue their charge to a top four finish with a win over a Lecce side battling to distance themselves from a relegation battle.
The match between the Biancocelesti and the Salentini kicks off at 19.45 UK time at the Stadio Olimpico in Rome.
Lazio currently find themselves third in the Serie A table with 64 points, just three ahead of fifth place Milan, so they cannot afford to drop points in the final stages of this season if they want to secure a return to the Champions League.
Maurizio Sarri’s side cannot count on Danilo Cataldi, who is dealing with a calf injury, but have recovered Matias Vecino, although the Uruguayan is unlikely to start.
Lecce sit 16th in the league table with just 31 points, leaving them just four ahead of relegation candidates Spezia. Every point matters now for the Puglian outfit as they look to avoid being sucked into the bottom three spots.
Lecce’s only absence is Kastriot Dermaku, who is sidelined with a muscle problem.
Probable line-ups for Lazio vs Lecce
Lazio (4-3-3): Provedel; Marusic, Casale, Romagnoli, Hysaj; Milinkovic-Savic, Marcos Antonio, Luis Alberto; Felipe Anderson, Immobile, Zaccagni.
Lecce (4-3-3): Falcone; Gendrey, Baschirotto, Umtiti, Gallo; Blin, Hjulmand, Oudin; Strefezza, Ceesay, Banda.