Lazio are short of options in central midfield, while Milan are without the suspended Adrien Rabiot, but Massimiliano Allegri will rely on Rafael Leao and Christian Pulisic in attack for a key away game at the Olimpico in Rome tonight.
It kicks off at 20:45 CET (19:45 GMT).
Samuel Gigot, Nicolò Rovella, Ivan Provedel, Danilo Cataldi and Toma Basic are unavailable for the Biancocelesti and even Alessio Romagnoli is not expected to be called up due to an injury.
According to several media, including Sky Sport Italia, centre-back Patric will play as a central midfielder, joining Kenneth Taylor and Fisayo Dele-Bashiru.
Milan have travelled to Rome without the injured Ruben Loftus-Cheek and Matteo Gabbia, while Adrien Rabiot is serving a one-game ban.
Pervis Estupinan is favourite over Davide Bartesaghi after scoring the winning goal in last week’s derby against Inter.
Milan sit second in the Serie A table, but a win in today’s match would allow them to move five points below leaders Inter, who were held to a 1-1 stalemate by Atalanta at San Siro on Saturday.
Lazio vs. Milan – where to watch on TV
The match will be broadcast live on TNT Sports 1 and DAZN in the UK and Ireland and on Paramount+ in the USA. Football Italia will provide live updates via a liveblog.
Lazio vs. Milan – probable line-ups
Milan (3-5-2): Maignan; Tomori, De Winter, Pavlovic; Saelemaekers, Fofana, Modric, Jashari, Estupiñán; Leão, Pulisic.
Lazio (4-3-3): Motta; Marusic, Gila, Provstgaard, Tavares; Dele-Bashiru, Patric, Taylor; Isaksen, Maldini, Zaccagni.
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