Danilo and Manuel Locatelli are expected to return to Juventus‘ starting XI, while Juan Jesus will partner Amir Rrahmani in central defence for Napoli.
It kicks off at 19:45 GMT at the Allianz Stadium in Turin tonight.
Juventus are without the injured Timothy Weah and Mattia De Sciglio, plus the suspended Nicolò Fagioli and Paul Pogba.
However, Danilo and Locatelli are fit to start, so they will return to the starting XI one week after featuring in a 2-1 win over Monza as substitutes.
Dusan Vlahovic and Federico Chiesa will start for the third consecutive game in attack, leaving Arek Milik and Moise Kean initially on the bench.
Napoli must cope without the injured Mario Rui and Mathias Olivera, so Natan will start at left-back with Rrahmani and Juan Jesus in central defence and captain Giovanni Di Lorenzo on the right flank.
The Italy international has had muscle issues this week but is fit to play in Turin tonight.
Piotr Zielinski is expected to return to Napoli’s line-up, joining André Zambo Anguissa and Stanislav Lobotka in midfield. The front three won’t change with Khvicha Kvaratskhelia, Victor Osimhen and Matteo Politano starting.
Juventus-Napoli: probable line-ups
Juventus (3-5-2): Szczesny; Gatti, Bremer, Danilo; Cambiaso, McKennie, Locatelli, Rabiot, Kostic; Vlahovic, Chiesa.
Napoli (4-3-3): Meret; Di Lorenzo, Rrahmani, Juan Jesus, Natan; Lobotka, Anguissa, Zielinski; Politano, Osimhen, Kvaratskhelia.