It kicks off at 19:45 BST at San Siro.
The Nerazzurri have had a perfect start with five wins in five games. They have scored 14 goals conceding just once.
Simone Inzaghi is not expected to rotate much. Marko Arnautovic is injured, so Lautaro Martinez and Thuram will start in attack. Davide Frattesi is tipped to start on the bench against his former club.
Sassuolo have two main doubts with Ruan Tressoldi favourite over Mattia Viti in central defence and Matias Vina expected to start as left-back, leaving Marcus Holmgren Pedersen initially on the bench.
If this will be the case, then Davide Dionisi would not change the starting line-up that beat Juventus at the Mapei Stadium this past Saturday.
Former Inter striker Pinamonti will start in attack for the Neroverdi after scoring four goals in the opening five Serie A matches.
Inter-Sassuolo: probable line-ups
Inter (3-5-2): Sommer; Pavard, Acerbi, Bastoni; Dumfries, Barella Calhanoglu, Mkhitaryan, Dimarco; Thuram, Lautaro.
Sassuolo (4-2-3-1): Cragno; Toljan, Erlic, Ruan Tressoldi, Viña; Boloca, Matheus Henrique; Berardi, Bajrami, Laurentiè; Pinamonti.