Vincenzo Italiano is expected to make a handful of changes to the team that lined up for the Coppa Italia final against Inter when Jose Mourinho and Roma visit in Serie A on Saturday afternoon.
Igor is expected to come in to start in place of Lucas Martinez Quatra at centre-back in an otherwise unchanged defensive set-up.
Rolando Mandragora is also in line to come in to start next to in a midfield combination with Sofyan Amrabat and Giacomo Bonaventura, with Gaetano Castrovilli set to be given a rest from the starting line-up.
Meanwhile, Mourinho’s options are still relatively limited after a series of unfortunate injuries to key first team players.
The Giallorossi are expected to welcome Diego Llorente back into the starting line-up, who could play alongside Roger Inabez and 18-year-old Dimitrios Keramitsis for what would be only the second league appearance of his career if Chris Smalling is unable to play.
Edoardo Bove is tipped to partner Benjamin Tahirovic in a fresh-face midfield pairing, flanked by Zeki Celik and Nicola Zalewski at wing-back.
Stephan El Shaarawy could also be in line for a start, playing next to Ola Solbakken, who together, will provide the support for Andrea Belotti in attack.
Kick off at the Stadio Artemio Franchi is at 17.00 UK time.
Fiorentina (4-3-3): Cerofolini; Dodo, Milenkovic, Igor, Biraghi; Mandragora, Amrabat, Bonaventura; Nico Gonzalez, Cabral, Ikone.
Roma (3-4-2-1): Svilar; Keramitsis, Llorente, Ibanez; Celik, Bove, Tahirovic, Zalewski; El Shaarawy; Solbakken; Belotti.