Empoli look to Francesco Caputo and Martin Satriano, while Sasa Lukic, who is in talks with Fulham, starts on the bench for Torino and Brian Bayeye makes his Serie A debut.
It kicks off at 14.00 GMT.
Liam Henderson and Fabiano Parisi are suspended for the Tuscans, while Mattia Destro and Alberto Grassi are injured.
With one goal Caputo will join Antonio Di Natale with 18 Empoli goals, becoming the fifth most prolific player in the club’s history. He has scored already scored four goals against Torino in his career.
Empoli won the last two Serie A matches and the last three home games.
David Zima and Koffi Djidji are injured for the Granata and the same is true of Pietro Pellegri and Valentino Lazaro.
Ola Aina is back and Sasa Lukic is available but doesn’t start, being not fully fit and in talks with Premier League side Fulham.
Bayeye makes his Serie A debut starting on the right in place of Wilfried Singo while Demba Seck gets the nod in attack with Antonio Sanabria on the bench.
Empoli-Torino: confirmed line-ups
Empoli (4-3-1-2): Vicario; Ebuehi, De Winter, Luperto, Cacace; Akpa Akpro, Marin, Bandinelli; Baldanzi; Satriano, Caputo.
Torino (3-4-2-1): Milinkovic-Savic; Schuurs, Buongiorno, Rodriguez; Bayeye, Ricci, Linetty, Vojvoda; Radonjic, Vlasic; Seck.
Empoli-Torino: live updates