Everything is at stake here, as Inter need a victory to keep their Scudetto dream alive and Cagliari can climb out of the relegation zone with a win.
It kicks off at the Unipol Domus Sardegna Arena at 19.45 UK time (18.45 GMT).
Serie A Liveblog: Milan-Atalanta, Cagliari-Inter, Napoli-Genoa, Bologna-Sassuolo
The Nerazzurri are feeling confident after Wednesday’s 4-2 extra time Coppa Italia Final victory over Juventus, which gave them the trophy after 11 years, their second of the season following the Supercoppa Italiana.
Matias Vecino is the only absentee, with Alessandro Bastoni available in the starting XI after his injury.
Cagliari know Salernitana were held to a draw, so a win here would see them leapfrog Davide Nicola’s side out of the bottom three.
Boris Radunovic is suspended, with Nahitan Nandez still injured, so Joao Pedro and Leonardo Pavoletti lead the attack.
Cagliari: Cragno; Altare, Ceppitelli, Lykogiannis; Bellanova, Rog, Grassi, Marin, Dalbert; Joao Pedro, Pavoletti
Inter: Handanovic; Skriniar, De Vrij, Bastoni; Darmian, Barella, Brozovic, Calhanoglu, Perisic; Lautaro Martinez, Dzeko