Walter Mazzarri makes his second debut on Napoli‘s bench with Khvicha Kvaratskhelia, Giacomo Raspadori and Matteo Politano in attack against Gian Piero Gasperini’s Atalanta.
It kicks off at 17:00 GMT at the Gewiss Stadium in Bergamo.
Mazzarri replaced Rudi Garcia during the break, returning to Napoli after ten years.
Mario Rui and Jesper Lindstrom are injured, but Victor Osimhen is available again and will start on the bench being still not fully fit, just like Alex Meret.
Jens Cajuste is favourite over André Zambo Anguissa in central midfield as the former Fulham man returned from international duty on Friday. Natan and Amir Rrahmani are expected to start in central defence.
Gasperini must cope without the suspended Marten de Roon, but Giorgio Scalvini, Davide Zappacosta and Charles De Ketelaere are back in action.
The Italians are expected to start while CDK could be involved in the second half, making room for Ademola Lookman and Gianluca Scamacca in Atalanta’s attack.
El Bilal Touré, José Luis Palomino and Rafael Toloi are injured.
Atalanta vs. Napoli – probable line-ups
Atalanta (3-4-1-2): Carnesecchi; Scalvini, Djimsiti, Kolasinac; Zappacosta, Koopmeiners, Ederson, Ruggeri; Pasalic; Scamacca, Lookman.
Napoli (4-3-3): Gollini; Di Lorenzo, Rrahmani, Natan, Olivera; Cajuste, Lobotka, Zielinski; Politano, Raspadori, Kvaratskhelia.