Atalanta will rotate after a 0-0 draw against Arsenal on Thursday, while Cesc Fabregas’ Como are looking for their first victory in Serie A this season.
It kicks off at 20:45 CET (18:45 GMT) and it’s the final match of Serie A Round 5.
Home side Atalanta must cope without the injured Ben Godfrey, Rafael Toloi, Gianluca Scamacca and Giorgio Scalvini.
Italian centre-back Federico Barba is the only absentee for Como.
Fabregas’ men have yet to win a Serie A match this season, collecting just two points in four games.
On the other hand, Atalanta have six points in four matches. The Nerazzurri held Arsenal to a 0-0 draw on their 2024-25 Champions League debut on Thursday last week.
Marco Brescianini is expected to start as an attacking midfielder for La Dea, while Mario Pasalic could replace Ederson or Marten de Roon in the middle of the park.
Maximo Perrone and Nico Paz will once again start for Como, while Andrea Belotti is expected to go on the bench again.
Atalanta vs Como – probable line-ups
Atalanta (3-4-1-2): Carnesecchi; Kossounou, Hien, Djimsiti; Bellanova, Pasalic, Ederson, Ruggeri; Brescianini; Retegui, Lookman.
Como (4-2-3-1): Audero; Iovine, Dossena, Kempf, Moreno; Sergi Roberto, Perrone; Strefezza, Paz, Fadera; Cutrone.