Daniele Doveri will officiate Juventus–Inter this weekend, while Daniele Orsato takes the Rome Derby and Maurizio Mariani judges the top of the table showdown Atalanta–Napoli.
It is going to be a fascinating weekend of Serie A action with some massive fixtures all taking place.
The Derby d’Italia is always a controversial clash that is difficult to officiate and for the fourth time that task goes to Doveri.
He already oversaw this meeting in January when Inter beat Juve for the Supercoppa Italiana in extra time.
Orsato has been assigned to the Derby della Capitale, which is also a head-to-head for third place between bitter rivals Roma and Lazio.
Mariani will have to rule when leaders Napoli visit second-placed Atalanta at the Gewiss Stadium.
Serie A Week 13
Udinese-Lecce (Ref Fourneau, VAR Massa)
Empoli–Sassuolo (Ref Feliciani, VAR Pairetto)
Salernitana-Cremonese (Ref Marchetti, VAR Valeri)
Atalanta-Napoli (Ref Mariani, VAR Irrati)
Milan–Spezia (Ref Fabbri, VAR Banti)
Bologna–Torino (Ref Giua, VAR Nasca)
Monza-Verona (Ref Cosso, VAR Abbattista)
Sampdoria–Fiorentina (Ref Marinelli, VAR Marini)
Roma-Lazio (Ref Orsato, VAR Mazzoleni)
Juventus-Inter (Ref Doveri, VAR Di Paolo)