Victor Osimhen, Hirving Lozano and Diego Demme are out of the trip to Rangers, so Napoli must reshuffle their attack in the Champions League trip to Glasgow, picking between Giovanni Simeone and Giacomo Raspadori.
It kicks off at Ibrox at 20.00 UK time (19.00 GMT) on Wednesday.
The original fixture was meant to be this evening, but postponed by 24 hours due to security concerns, as policing is already stretched during mourning for the Queen.
Osimhen is out of action after sustaining a muscular strain during the 4-1 win over Liverpool, while Lozano is struggling with flu symptoms.
This means a change for Luciano Spalletti, and the big choice is between Giovanni Simeone and Giacomo Raspadori upfront.
Both were late signings in the transfer window, but while Simeone is more of a centre-forward and scored on his Champions League debut against Liverpool, there are more question marks around Raspadori.
The former Sassuolo striker can play in a variety of roles and has so far shown he is more suited to a support slot at Napoli.
Cholito Simeone is therefore the favourite, with on-form Matteo Politano and Kvicha Kvaratskhelia completing the trident.
Mathias Olivera is expected to start at left-back rather than Mario Rui.
Napoli squad for Rangers: Meret, Sirigu, Idasiak, Di Lorenzo, Zanoli, Rrahmani, Ostigard, Kim Min-jae, Juan Jesus, Mario Rui, Mathias Olivera, Lobotka, Anguissa, Zielinski, Ndombele, Elmas, Zerbin, Gaetano, Kvaratskhelia, Simeone, Politano, Raspadori