Italy internationals Marco Verratti and Gianluigi Donnarumma start for PSG, with Neymar on the bench, as Carlo Ancelotti relies on Karim Benzema for Real Madrid.
The first leg of the Champions League Round of 16 tie kicks off in Paris at 20.00 GMT.
An Italian is also refereeing, as Daniele Orsato wields the whistle with Massimiliano Irrati in the VAR booth.
Verratti is increasingly the key to the Paris Saint-Germain midfield and he pulls the strings, with Donnarumma getting the nod rather than Keylor Navas in goal.
Sergio Ramos and Ander Herrera are injured, with Neymar only fit for the bench after several months out with a bad ankle sprain.
Instead, Lionel Messi is flanked by Angel Di Maria and Kylian Mbappé.
Real Madrid are coached by Carlo Ancelotti, who is only missing Mariano Diaz from the squad.
Benzema had been in doubt with a muscular issue, but he is in the starting XI with support from Marcos Asensio and Vinicius Junior, leaving Rodrygo on the touchline.
PSG: Donnarumma; Hakimi, Marquinhos, Kimpembe, Nuno Mendes; Danilo, Paredes, Verratti; Di Maria, Messi, Mbappé
Real Madrid: Courtois; Carvajal, Militao, Alaba, F Mendy; Kroos, Casemiro, Modric; Asensio, Benzema, Vinicius
Go real beat the P$G and make Dollarama cry.