Lazio will be looking to step back into the top four with a win over Fiorentina before league leaders Napoli host Roma in the Derby del Sole.
The match between the Biancocelesti and the Viola kicks off at 17.00 UK time at the Stadio Olimpico. In the evening, Napoli host Roma at the Stadio Diego Armando Maradona at 19.45.
Maurizio Sarri cannot count on Mario Gila and Stefan Radu, both of whom are out injured. The Lazio coach will be hoping to include both Adam Marusic and Ciro Immobile in his matchday squad, but both are in doubt. Nicolo Casale, Adam Marusic and Danilo Cataldi are all a booking away from suspension.
Fiorentina are without Gaetano Castrovilli and Riccardo Sottil, both sidelined with injuries. Arthur Cabral is in doubt due to a muscle issue. Rolando Mandragora and Igor will be wary of picking up a yellow card, being one away from suspension.
Probable line-ups for Lazio vs Fiorentina:
Lazio (4-3-3): Provedel; Lazzari, Casale, Romagnoli, Marusic; Milinkovic-Savic, Cataldi, Luis Alberto; Pedro, Felipe Anderson, Zaccagni.
Fiorentina (4-2-3-1): Terracciano; Dodò, Milenkovic, Igor, Biraghi; Duncan, Amrabat; Ikoné, Bonaventura, Saponara; Kouamé.
The League leaders will be confident heading into the Derby del Sole, having a fully fit squad. The only slight concern is defender Kim Min-Jae, who is one yellow card away from being suspended.
Roma are without Ebrima Darboe and Georginio Wijnaldum, both out with injuries. Zeki Celik is suspended and Nicolo Zaniolo has been excluded due to his transfer market situation. Gianluca Mancini, Chris Smalling and Bryan Cristante are all a booking away from a one-game ban.
Probable line-ups for Napoli vs Roma:
Napoli (4-3-3): Meret; Di Lorenzo, Rrahmani, Kim, Mario Rui; Anguissa, Lobotka, Zielinski; Elmas, Osimhen, Kvaratskhelia.
Roma (3-4-2-1): Rui Patricio; Mancini, Smalling, Ibanez; Zalewski, Cristante, Matic, Spinazzola; Dybala, Pellegrini; Abraham.