Roma return to the pitch after their defeat with Bodo/Glimt with Nicolò Zaniolo available, while Politano is the favourite to start over Hirving Lozano in Napoli’s attack.
It kicks off at 17.00 UK time at the Stadio Olimpico in Rome.
José Mourinho’s side return to the pitch after the mid-week embarrassment against Bodo/Glimt in the Conference League.
Nicolò Zaniolo has recovered from an injury and is expected to start at left winger for the Giallorossi.
The Special One will pick his classic Roma XI in the game against Serie A leaders Napoli.
Luciano Spalletti can count on Piotr Zielinski who precautionarily sat out Napoli’s Europa League match against Legia Warsaw on Thursday.
The Tuscan tactician has only one doubt in attack, but Politano should start over Lozano in the Partenopei’s attacking trident.
Probable line-ups: Roma vs. Napoli
Roma: Rui Patricio; Karsdorp, Mancini, Ibanez, Vina; Cristante, Veretout; Zaniolo, Pellegrini, Mkhitaryan; Abraham.
Napoli: Ospina; Di Lorenzo, Rrahmani, Koulibaly, Mario Rui; Anguissa, Fabian Ruiz, Zielinski; Politano, Osimhen, Insigne.