Roma are expected to give Stephan El Shaarawy a starring role with Edin Dzeko and Henrikh Mkhitaryan, while Lazio have Sergej Milinkovic-Savic back with a protective face mask.
It kicks off at 19.45 UK time (18.45 GMT), click here for a match preview.
The Giallorossi continue to deal with an extensive injury list that rules out Jordan Veretout, Pau Lopez, Chris Smalling, Leonardo Spinazzola, Amadou Diawara, Carles Perez, Riccardo Calafiori and Nicolò Zaniolo.
Roma are expected to give Stephan El Shaarawy a starring role with Edin Dzeko and Henrikh Mkhitaryan, while Lazio have Sergej Milinkovic-Savic back with a protective face mask.
It kicks off at 19.45 UK time (18.45 GMT), click here for a match preview.
The Giallorossi continue to deal with an extensive injury list that rules out Jordan Veretout, Pau Lopez, Chris Smalling, Leonardo Spinazzola, Amadou Diawara, Carles Perez, Riccardo Calafiori and Nicolò Zaniolo.
Gonzalo Villar does return and Gianluca Mancini is available again after suspension.
El Shaarawy is expected to start in place of Pedro, with Mkhitaryan and Lorenzo Pellegrini in support of Pedro.
As for Lazio, Lucas Leiva and Andreas Pereira are back from their bans, and the most notable return is Milinkovic-Savic.
He fractured his nose during the 2-0 defeat to Fiorentina, playing on in the second half despite the nasty clash of heads with Erick Pulgar.
Having missed the 1-0 win over Parma and had surgery, the Serbian is rushing back to start with the aid of a protective mask.
Adam Marusic should return to the back three, as Luiz Felipe is not at 100 per cent, with Pepe Reina preferred to Thomas Strakosha in goal.
Probable line-ups
Roma: Fuzato; Karsdorp, Mancini, Ibanez, Peres; Villar, Cristante; Mkhitaryan, Pellegrini, El Shaarawy; Dzeko
Lazio: Reina; Marusic, Acerbi, Radu; Lazzari, Milinkovic-Savic, Leiva, Luis Alberto, Lulic; Immobile, Correa
Ref: Pairetto