Juventus are expected to start with Luca Pellegrini at left and Dejan Kulusevski up front, when Napoli coach Luciano Spalletti should give André Zambo Anguissa his first start.
The match kicks off at 17.00 UK time.
The Old Lady has big problems ahead of the trip to Naples, as Massimiliano Allegri confirmed the South Americans are absent and the club announced Federico Chiesa will not take part.
Napoli are looking for their third win on the bounce, while Juve return to Serie A after a tough start with only one point from two rounds of fixtures.
Victor Osimhen returns for the home side, as his ban was reduced to one game, and reports in Italy claim Matteo Politano seems set to start over Hirving Lozano.
Piotr Zielinski is called up for the game but is not 100 per cent and should start on the bench, as Anguissa is set for his debut after arriving from Fulham on deadline day.
Allegri has not called up the South Americans travelling for the World Cup Qualifiers this month and is thus without Rodrigo Bentancur, Paulo Dybala, Alex Sandro and Danilo.
Juan Cuadrado who would have returned in time, is also absent, as he remained in Colombia due to gastroenteritis.
Allegri will neither risk Chiesa, who is not 100 per cent after the games with Italy in the World Cup Qualifiers and seems set to start Pellegrini at left in a 3-5-2 formation.
Napoli (probable): Ospina; Di Lorenzo, Manolas, Koulibaly, Mario Rui; Anguissa, Fabian; Politano, Elmas, Insigne; Osimhen
Juventus (probable): Szczesny; De Ligt, Bonucci, Chiellini; De Sciglio, McKennie, Locatelli, Rabiot, Pellgrini; Morata, Kulusevski
Ref: Irrati (VAR: Mariani)
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