The attacking crisis continues for Napoli coach Gennaro Gattuso and the Partenopei are expected to change formation in the second leg against Granada.
The match kicks off at 17.55 UK time.
Napoli have a mountain to climb for a place in the last 16 of the Europa League, as they trail the La Liga side by 2-0 after the first leg in Spain.
The last time Napoli turned around a 2-0 defeat from the first leg in Europe was in 1989, when the Azzurri beat Juventus in the UEFA Cup.
The attacking crisis continues for Napoli coach Gennaro Gattuso and the Partenopei are expected to change formation in the second leg against Granada.
The match kicks off at 17.55 UK time.
Napoli have a mountain to climb for a place in the last 16 of the Europa League, as they trail the La Liga side by 2-0 after the first leg in Spain.
The last time Napoli turned around a 2-0 defeat from the first leg in Europe was in 1989, when the Azzurri beat Juventus in the UEFA Cup.
Victor Osimhen, Andrea Petagna and Hirving Lozano are unavailable for the Azzurri but Gattuso could have Dries Mertens back for some minutes towards the end.
The coach is expected to change the formation to 3-4-1-2, with Lorenzo Insigne and Matteo Politano playing up front a Piotr Zielinski in support.
The Azzurri coach has reportedly decided to start with a back-three and
Alex Meret continues in goal, protected by Amir Rrahmani, Kalidou Koulibaly and Nikola Maksimovic.
Tiemoue Bakayoko and Fabio Ruiz should start in the middle, as Giovanni Di Lorenzo and Eljif Elmas could get the nod out wide.
Granada are expected to arrive in a 4-3-2-1 with Jorge Molina up front, supported by Kenedy and Darwin Machis, completing the attacking trident.
Napoli (probable): Meret; Rrahmani, Koulibaly, Maksimovic; Di Lorenzo, Fabian Ruiz, Bakayoko, Elmas; Zielinski; Politano, Insigne
Granada (probable): Rui Silva; Victor Diaz, Duarte, German, Neva; Herrera, Gonalons, Montoro; Machis, Kenedy; Molina
Referee: Siebert (GER)