Zlatan Ibrahimovic and Sandro Tonali are expected to start against Inter, while Hakan Calhanoglu will play his first derby against the Rossoneri.
The Derby della Madonnina kicks off at 19.45 UK time.
Milan are the Serie A table leaders on even points with Napoli and Inter follow them seven points behind.
Junior Messias is the only Milan player out of action as Alessandro Florenzi, Ante Rebic and Fode Ballo-Touré have recovered in time for the game. Theo Hernandez is suspended and will be replaced by the former Monaco starlet of Pierre Kalulu.
Ibrahimovic is likely to start up front with Olivier Giroud initially on the bench.
Either Brahim Diaz or Alexis Saelemaekers will start at right winger with Rade Krunic picked as the attacking midfielder.
Hakan Calhanoglu will play his first game against the Rossoneri, starting in the Inter midfield with Marcelo Brozovic and Nicolò Barella.
Matteo Darmian is the favourite to start over Denzel Dumfries on the right, with Edin Dzeko and Lautaro Martinez in attack.
Simone Inzaghi can rely on full squad for the match against the Rossoneri.
Probable line-ups
Milan: Tatarusanu; Calabria, Kjaer, Tomori, Ballo-Touré; Tonali, Kessié; Brahim Diaz, Krunic, Leao; Ibrahimovic.
Inter: Handanovic; Skriniar, De Vrij, Bastoni; Darmian, Barella, Brozovic, Calhanoglu, Perisic; Dzeko., Lautaro.
Best 11 from the 2 line-ups above?
Mine would be:
Handanovic
Skriniar – De Vrij – Bastoni
Calabria – Barella – Brozovic or Tonali – Kessie – Perisic
Martinez – Ibrahimovic