Stephan El Shaarawy is expected to replace the suspended Lorenzo Pellegrini in the Rome derby, while Maurizio Sarri will look to Ciro Immobile, Pedro and Felipe Anderson.
The Rome derby kicks off at the Stadio Olimpico at 17.00 UK time.
Roma captain Lorenzo Pellegrini saw red against Udinese earlier this week, so he is suspended for the big match against Lazio.
José Mourinho should replace the Italian with El Shaarawy. Chris Smalling could start on the bench with Gianluca Mancini and Roger Ibanez at centre-back, Rick Karsdorp and Matias Vina chosen as the starting full-backs.
Maurizio Sarri won’t rotate his Lazio squad much, picking the usual attacking trident with Ciro Immobile, Pedro and Felipe Anderson.
Lucas Leiva is not fully fit, so Sarri is considering starting Danilo Cataldi in the middle of the park.
Probable line-ups: Lazio vs. Roma
Lazio: Reina; Lazzari, Luiz Felipe, Acerbi, Hysaj; Milinkovic, Leiva, Luis Alberto; Pedro, Immobile, Felipe Anderson.
Roma: Rui Patricio; Karsdorp, Mancini, Ibanez, Vina; Cristante, Veretout; Zaniolo, Mkhitaryan, El Shaarawy; Abraham.