Lazio coach Maurizio Sarri seems set to give Danilo Cataldi, Jean-Daniel Akpa-Akpro and Raul Moro the go ahead against Lokomotiv Moscow in the Europa League.
The match at the Olimpico kicks off at 20.00 
The Biancocelesti arrive from an important win over Roma last time but their Europa League campaign is already difficult after the defeat to Galatasaray in the first leg.
Lazio aim to pick up three points at home against Lokomotiv Moscow, but Sarri is expected to rotate to keep his players fresh for the upcoming League game too.
The matches are too close for Sarri and at the press conference he seemed annoyed with the Lega, meaning he will most likely make some changes to the team.
Ciro Immobile could still start up front over Vedat Muriqi, but Luis Alberto and Lucas Leiva should rest.
Raul Moro seems set to be given a chance to replace Pedro Rodriguez and Thomas Strakosha is confirmed in goal, despite the performance against the Turkish side in the first leg.
Probable line-ups: Lazio vs. Lokomotiv Moscow
Lazio (4-3-3): Strakosha; Lazzari, Luiz Felipe, Acerbi, Radu; Milinkovic, Cataldi, Akpa-Akpro; Felipe Anderson, Immobile, Raul Moro
Lokomotiv Moscow (4-3-1-2): Guilherme; Zhivoglyadov, Barinov, Pablo, Silyanov; Beka, Maradishvili, Kulikov; Zhemaletdinov; Kerk, Smolov