Inter are expected to use their strongest XI including Nicolò Barella, Federico Dimarco and Marcus Thuram, while Roma should again have Stephan El Shaarawy supporting Romelu Lukaku.
It kicks off at San Siro on Sunday at 17.00 GMT.
The Nerazzurri showed how much importance they put on this match by resting several star names for the Champions League victory over RB Salzburg midweek.
Those include Barella, Dimarco, Thuram and Francesco Acerbi, all of whom are expected to be back in the line-up tomorrow evening.
Lautaro Martinez is Capocannoniere and on track to break the record with 11 goals in nine Serie A games so far this season.
Juan Cuadrado and Marko Arnautovic are still out of action.
Roma coach Jose Mourinho is suspended and expected to watch either in the stands or from the team bus, which he has been known to do during these touchline bans.
The injury list remains extensive, as Paulo Dybala, Lorenzo Pellegrini, Renato Sanches, Leonardo Spinazzola, Chris Smalling, Tammy Abraham and Marash Kumbulla did not make the trip.
Mourinho said after the 2-0 Europa League win over Slavia Prague on Thursday that Andrea Belotti with Lukaku would struggle against a three-man defence, so he preferred someone like El Shaarawy – in the absence of Dybala and Pellegrini – to tie the midfield and attack together.
This all points towards the Little Pharaoh acting as support for ex-Inter hitman Lukaku.
Diego Llorente returned to defence midweek, allowing Bryan Cristante to play in his preferred midfield spot.
Probable line-ups
Inter (3-5-2): Sommer; Pavard, Acerbi, Bastoni; Dumfries, Barella, Calhanoglu, Mkhitaryan, Dimarco; Lautaro Martinez, Thuram
Roma (3-5-2): Rui Patricio; Mancini, Llorente, Ndicka; Karsdorp, Cristante, Paredes, Bove, Zalewski; Lukaku, El Shaarawy