Coach Paulo Fonseca could make seven changes from the team that beat Parma in Serie A, when Roma visit CFR Cluj in the Europa League.
The match kicks off at 20.00 UK time.
The Giallorossi, who are third in Serie A and top of Group A in the Europa League, could secure a place in the round of 32 with a win in Romania.
But Fonseca seems set to make a host of changes from the team that beat Parma 3-0 at the weekend but will most likely keep Edin Dzeko on the bench.
Coach Paulo Fonseca could make seven changes from the team that beat Parma in Serie A, when Roma visit CFR Cluj in the Europa League.
The match kicks off at 20.00 UK time.
The Giallorossi, who are third in Serie A and top of Group A in the Europa League, could secure a place in the round of 32 with a win in Romania.
But Fonseca seems set to make a host of changes from the team that beat Parma 3-0 at the weekend but will most likely keep Edin Dzeko on the bench.
The Bosnia international returned from COVID-19 this week, but will be spared for the big game against Napoli in the League.
Chris Smalling, Roger Ibanez, Gianluca Mancini and Marash Kumbulla are out and Federico Fazio has just returned from coronavirus.
Bryan Cristante and Juan Jesus seem set to start in the heart of the defence, with Rick Karsdorp and Bruno Peres fighting for a place at right.
Youngster Riccardo Calafiori seems set to start at left-back, if Fonseca decides to play four at the back.
On the other hand, he could start with a back-three and shuffle the pack, but Amadou Diawara is expected to start in the middle with Gonzalo Villar.
In a 4-2-3-1, Carles Perez, Lorenzo Pellegrini and Pedro Rodriguez could be in the attacking trident, with Borja Mayoral up front.
Cluj have picked up four points from three games so far, but Dan Pretescu must cope without six first-team players ahead of the match and seems set to start with a 4-3-3.
Cluj (probable): Balgradean; Susic, Ciobotariu, Burca, Camora; Itu, Djokovic, Paun; Rondon, Debeljuh, Pereira
Roma (probable): Pau Lopez; Bruno Peres, Cristante, Juan Jesus, Calafiori; Villar, Diawara; Carles Perez, Pellegrini, Pedro; Borja Mayoral
Referee: Lechner (AUT)