Lautaro Martinez, Nicolò Barella and Alessandro Bastoni are expected to start on the bench against Real Sociedad tonight, while Juan Cuadrado will replace Denzel Dumfries on the right wing.
It kicks off at 20:00 GMT at the Stadio Meazza.
The Nerazzurri have already qualified for the Round of 16 but must beat the La Liga side tonight to win their group. Benjamin Pavard, Stefan de Vrij and Dumfries are injured and Simone Inzaghi is expected to do some rotations.
Stefano Sensi is also not available as he was left out of Inter‘s UEFA list in September.
Bastoni, Barella and Lautaro will likely start on the bench, making room for Carlos Augusto, Davide Frattesi and Alexis Sanchez in the starting XI.
Bastoni has recently returned from a calf injury and played 60 minutes in Inter’s 4-0 win over Udinese on Saturday.
Matteo Darmian will join Carlos Augusto and Francesco Acerbi in a three-man defence, with Cuadrado deployed on the right flank.
Inter-Real Sociedad, probable line-ups
Inter (3-5-2): Sommer; Darmian, Acerbi, Carlos Augusto; Cuadrado, Frattesi, Calhanoglu, Mkhitaryan, Dimarco; Sanchez, Thuram.
Real Sociedad (4-3-3): Remiro; Traoré, Zubeldia, Le Normand, Tierney; Marin, Zubimendi, Merino; Kubo, Sadiq, Barrenetxea.