Matteo Politano and Adam Ounas return for Napoli against Sassuolo, but Kostas Manolas pulls out with gastroenteritis.
The Partenopei are three points clear at the top of the Serie A table after tearing Lazio apart 4-0.
Politano returns to the squad after testing positive for COVID-19 on November 20, after Diego Demme had already shaken off the virus.
Ounas has also recovered from a muscular injury that he sustained on international duty with Algeria.
However, Manolas will not be taking part in the trip because he came down with a case of gastroenteritis.
The Greek international had been tipped to start so Luciano Spalletti could rest some of his defenders for this midweek round.
Victor Osimhen, Andre Frank Zambo Anguissa and Alessandro Zanoli are still out of action.
Napoli squad for Sassuolo: Marfella, Meret, Ospina; Di Lorenzo, Ghoulam, Jesus, Koulibaly, Malcuit, Mario Rui, Rrahmani; Demme, Elmas, Ruiz, Lobotka, Zielinski; Insigne, Lozano, Mertens, Ounas, Petagna, Politano
✈️ Direzione ➡️ Reggio Emilia!
💙 #ForzaNapoliSempre pic.twitter.com/jkkU7K2PeD
— Official SSC Napoli (@sscnapoli) November 30, 2021