Politano has played in all 12 Serie games A this term, with Napoli joint first with Milan on 32 points, seven above Inter at third.
The 28-year-old moved to Naples from the Nerazzurri in January 2020, initially on loan before making the transfer permanent in July 2021.
Inter won the Scudetto last term and Politano is aware of the strength of the Beneamata ahead of the big game this weekend.
“It will be an important match that will open a cycle of battles until the end of December,” Politano told Radio Kiss Kiss Napoli. “Our goal is always to win.
“We have to do well this month, thinking about giving our best every match. As San Siro it’s always fascinating. We’re up against a great team, but we are aware of having an advantage in the table.
“Our goal is to keep the Nerazzurri at a distance.”
The former Nerazzurro believes coach Spalletti has ‘much of the credit’ for the great start to the season.
“We are a united and solid group, the most compact I have ever played in,” Politano added. “We help each other, and this is fundamental, both on and off the pitch, to get great results.
“Much of the credit goes to Spalletti, who guides us with attention to every detail.”
Politano concluded by explaining the mental target of the Azzurri in 2021-22.
“Spalletti has so much energy that he transmits to us every day,” he continued. “This year we are looking for that maturity we were lacking in the past.
“We want to give continuity to the results, an aspect that becomes fundamental in the long run to achieve our objectives.”