Stefano Pioli has asked Milan to focus entirely on Liverpool and getting that victory, but not pay attention to the result from Porto and Atletico Madrid.
It kicks off at 20.00 GMT, you can follow all the build-up and action as it happens on the LIVEBLOG.
The Rossoneri need a victory to have any hope of qualifying for the Champions League Round of 16, while other results also need to go their way as FC Porto host Atletico Madrid.
“We must have the right approach, the team is ready and we hope to be up to the task,” Pioli told Sky Sport Italia.
“In these games, technical quality can make the difference, so we need to make the right decisions when we are allowed the spaces to play.
“We believe that we can have a great game and will try to win. We are not interested right now what happens in the other games, we’ll discover that at the end.”