Milan will look to Yunus Musah and Christian Pulisic, while Noah Okafor will replace the injured Alvaro Morata against Adrián Bernabé’s Parma.
It kicks off at 18:30 CET (16:30 GMT) at the Stadio Tardini.
The Ducali see Enrico Del Prato return from a one-match ban, so the 24-year-old Italian defender is expected to start in central defence with Drissa Camara confirmed as right-back.
Milan coach Paulo Fonseca has confirmed that Okafor would replace the injured Morata in the Rossoneri attack.
The Portuguese will make even more changes to his starting formation following last week’s 2-2 draw against Torino.
Ruben Loftus-Cheek will start as an attacking midfielder again, making room for Musah in central midfield. The USMNT international will join Tijjani Reijnders.
Malick Thiaw will also go on the bench, so summer signing Strahinja Pavlović will make his debut as a starter with the Rossoneri. Theo Hernandez will start as a left-back.
Alessandro Florenzi, Marco Sportiello, Morata and Yacine Adli are not available for the Rossoneri.
Parma vs Milan – where to watch on TV
Parma vs Milan is the first Serie A match that CBS Sports will broadcast live. The game is also available to stream on Paramount+ in the USA. Fans in the UK and Ireland can stream the match for free on OneFootball. Parma vs Milan is available on beIN SPORTS 3 and beIN SPORTS CONNECT in Australia and New Zealand.
Parma vs Milan – probable line-ups
Parma (4-2-3-1): Suzuki; Coulibaly, Delprato, Circati, Valeri; Estevez, Bernabé; Man, Sohm, Mihaila; Bonny.
Milan (4-2-3-1): Maignan; Calabria, Tomori, Pavlovic, Theo Hernandez; Musah, Reijnders; Pulisic, Loftus-Cheek, Leao; Okafor.