It’s a fascinating clash between on-form teams Fiorentina and Inter, with Dusan Vlahovic and Nicolas Gonzalez against Lautaro Martinez and Edin Dzeko.
It kicks off at the Stadio Franchi at 19.45 UK time (18.45 GMT).
These are two of the form sides in Serie A right now, as the Viola have won three on the bounce under new coach Vincenzo Italiano and the Nerazzurri hammered Bologna 6-1 at the weekend.
Vlahovic has picked up where he left off last season and Nicolas Gonzalez carrying a muscular issue, but can start with Riccardo Sottil.
Lorenzo Venuti, Erick Pulgar and Gaetano Castrovilli are ruled out by injury, so Marco Benassi is preferred to Alvaro Odriozola at right-back, with Matija Nastasic returning in the centre.
Inter lost Joaquin Correa to a bruised hip during their 6-1 win over Bologna, joining Stefano Sensi, Arturo Vidal and Christian Eriksen on the absentee list.
It means Dzeko returns as the partner to Lautaro Martinez, while Hakan Calhanoglu is back in midfield after he was rested.
Fiorentina: Dragowski; Benassi, Milenkovic, Nastasic, Biraghi; Bonaventura, Torreira, Duncan; Sottil, Vlahovic, Gonzalez
Inter: Handanovic; Skriniar, De Vrij, Bastoni; Darmian, Barella, Brozovic, Calhanoglu, Perisic; Dzeko, Lautaro Martinez