Spain make two changes to the XI that beat 10-man Italy, while France again rely on Theo Hernandez, but lose Adrien Rabiot for the Nations League Final.
It kicks off at San Siro, the Stadio Giuseppe Meazza in Milan, at 19.45 UK time (18.45 GMT).
This match decides the trophy, as Italy beat Belgium 2-1 this afternoon to secure third place in the tournament.
Spain squeezed past 10-man Italy in the semi-final with a Ferran Torres brace and coach Luis Enrique makes two changes to the starting XI.
Eric Garcia replaces Pau Torres in defence, with Rodri stepping in for Koke.
He sticks with 17-year-old Gavi in midfield, the Barcelona talent who was the youngest ever player to debut for Spain.
France fought back from 2-0 down to eliminate Belgium in a 3-2 thriller with Milan full-back Theo Hernandez scoring the stoppage-time winner.
He starts again, but brother Lucas Hernandez is dropped in favour of Presnel Kimpembe.
Juventus midfielder Rabiot has tested positive for COVID-19, so Bianconeri transfer target Aurelien Tchouameni steps in.
Spain: Unai Simon; Azpilicueta, Eric Garcia, Laporte, Alonso; Gavi, Busquets, Rodri; Sarabia, Ferran Torres, Oyarzabal
Spain bench: De Gea, Sanchez, Pau Torres, Inigo Martinez, Bryan Gil, Pino, Koke, Sergi Roberto, Reguilon, Pedro Porro, Fornals, Merino
France: Lloris; Koundé, Varane, Kimpembe; Pavard, Pogba, Tchouameni, Theo Hernandez; Griezmann; Mbappé, Benzema
France bench: Costil, Maignan, Martial, Diaby, Dubois, Guendouzi, Upamecano, Veretout, Ben Yedder, Lucas Hernandez
Ref: Taylor (ENG)