Napoli miss Walter Gargano, Ivan Strinic, Raul Albiol and Faouzi Ghoulam against Atalanta.
It kicks off on Sunday at 19.45 GMT, click here for a match preview.
The Partenopei are eager to get back on track after a disappointing defeat to Hellas Verona, though qualified for the Europa League quarter-finals thanks to their 0-0 draw at Dinamo Moscow.
Napoli miss Walter Gargano, Ivan Strinic, Raul Albiol and Faouzi Ghoulam against Atalanta.
It kicks off on Sunday at 19.45 GMT, click here for a match preview.
The Partenopei are eager to get back on track after a disappointing defeat to Hellas Verona, though qualified for the Europa League quarter-finals thanks to their 0-0 draw at Dinamo Moscow.
Gargano and Strinic are on the treatment table along with Michu, while Lorenzo Insigne is again on the bench four months after his knee injury.
Raul Albiol and Ghoulam sit out bans, so Rafa Benitez has to reshuffle his defence.
Bruno Uvini is recalled and there are reports Juan Camilo Zuniga could start.
Kalidou Koulibaly is back in action following his injury.
Napoli squad for Atalanta: Rafael, Andujar, Colombo, Maggio, Mesto, Uvini, Zuniga, Britos, Henrique, Koulibaly, Inler, David Lopez, Jorginho, De Guzman, Mertens, Callejon, Hamsik, Gabbiadini, Duvan Zapata, Insigne, Higuain