Massimiliano Allegri is expected to pick Luka Modric over Samuele Ricci against Cremonese, giving the ex-Real Madrid star his Serie A debut on Matchday 1.
It kicks off at 20:45 CET (19:45 BST) at the Stadio Meazza in San Siro, Milan.
The Rossoneri must cope without the injured Rafael Leao, who Santiago Gimenez will replace.
Allegri said on Saturday that he didn’t know whether he’d start Modric, but according to Italian media, including Gazzetta and Sky Sport, a decision has now been taken as the Croatian star will feature in the Rossoneri XI, joining Ruben Loftus-Cheek and Youssouf Fofana in the middle of the park.
Another new signing, Pervis Estupinan, will start as a left-back, while the returnee Alexis Saelemaekers will be part of a three-man attack with Gimenez and Christian Pulisic.
Newly promoted side Cremonese are without the suspended Franco Vazquez, Tommaso Barbieri and Mattia Valoti.
New coach Davide Nicola is expected to pick a 3-5-2 formation with Milan loanees Filippo Terracciano starting in a three-man defence and Warrne Bondo picked in the middle of the park.
Where to watch Milan vs Cremonese
The game will be broadcast live on DAZN in the UK and Paramount+ in the USA.
Milan vs Cremonese – Probable line-ups
Milan (4-3-3): Maignan; Tomori, Gabbia, Pavlovic, Estupinan; Loftus-Cheek, Modric, Fofana; Saelemaekers, Giménez, Pulisic.
Cremonese (3-5-2): Audero; Terracciano, Baschirotto, Bianchetti; Zerbin, Collocolo, Grassi, Vandeputte, Pezzella; Okereke, Bonazzoli.
for me i no like that 5 defense