Davide Calabria is expected to miss the Derby della Madonnina through injury, but Milan are considering a change of system with Tammy Abraham and Alvaro Morata together against Inter.
It kicks off at San Siro on Sunday at 19.45 UK time (18.45 GMT).
The Rossoneri have a lengthy injury list to deal with and it’s getting longer, because captain Calabria picked up a muscular problem during the 3-1 Champions League defeat to Liverpool on Tuesday evening.
According to the latest reports, the right-back is not going to be fit enough to participate in the derby.
There are suggestions that coach Paulo Fonseca could transform the 4-2-3-1 formation to a 4-4-2 in order to bring more solidity to their leaky defence.
This would mean having a double centre-forward, Abraham partnering Morata upfront, with neither of them probably fit enough for a full 90 minutes.
Ruben Loftus-Cheek is the player who could be shifted to the Milan bench, giving Christian Pulisic and Rafael Leao deeper roles.
Matteo Gabbia is also being tipped to replace Strahinja Pavlovic in the middle of the defence.
Probable Milan line-up
Milan (4-4-2): Maignan; Emerson Royal, Gabbia, Tomori, Theo Hernandez; Pulisic, Fofana, Reijnders, Leao; Morata, Abraham