Mario Rui and Matteo Politano are out of the Napoli squad travelling for tomorrow’s match against Bologna.
It kicks off at the Stadio Dall’Ara on Sunday at 14.00 UK time (13.00 GMT).
The Scudetto winners are still hoping to break Maurizio Sarri’s all-time club record for points in a single Serie A season.
Eljif Elmas sits out a ban, while Hirving Lozano is out with a knee injury.
Now Mario Rui has also been left behind, as he felt a muscular twinge in his right thigh.
Today is also the Portuguese full-back’s 32nd birthday, but he will not be marking it with a journey to Bologna.
Matteo Politano is also on the absentee list.