Roma start three summer signings in the UEFA Europa Conference League play-off against Trabzonspor, with Nicolò Zaniolo and Henrikh Mkhitaryan supporting Eldor Shomurodov.
It kicks off in the Senol Gunes stadium in Trabzon at 18.30 UK time.
The second leg is next Thursday evening at the Stadio Olimpico in Rome.
Jose Mourinho fields three new signings, including the debut for Matias Vina at left-back, along with goalkeeper Rui Patricio and ex-Genoa striker Shomurodov.
There are several familiar faces in the Trabzonspor side, such as ex-Roma players Bruno Peres and Gervinho, and former Napoli captain Marek Hamsik.
Andreas Cornelius just completed his transfer from Parma, but is not fit enough to start.
Line-ups
Trabzonspor: Ugurcan Cakir; Bruno Peres, Edgar Ie, Vitor Hugo, Koybasi; Hamsik, Ozdemir, Bakasetas; Gervinho, Djaniny, Nwakaeme
Roma: Rui Patricio; Karsdorp, Mancini, Ibanez, Vina; Cristante, Veretout; Zaniolo, Pellegrini, Mkhitaryan; Shomurodov