Torino start Simone Zaza and Andrea Belotti for the first time, but Napoli transform to a 4-4-2 formation with Simone Verdi and Dries Mertens.
It kicks off in Turin at 11.30 UK time (10.30 GMT).
Follow the build-up and action as it happens from all six Serie A games on the LIVEBLOG.
Torino start Simone Zaza and Andrea Belotti for the first time, but Napoli transform to a 4-4-2 formation with Simone Verdi and Dries Mertens.
It kicks off in Turin at 11.30 UK time (10.30 GMT).
Follow the build-up and action as it happens from all six Serie A games on the LIVEBLOG.
The Partenopei have stuttered in front of goal lately and after the 0-0 Champions League draw with Red Star Belgrade, Coach Carlo Ancelotti is ready to shake things up.
He moves away from Maurizio Sarri’s 4-3-3 formation and starts a 4-4-2 with Marko Rog and Marek Hamsik in midfield.
Verdi and Callejon take the wide roles, with Lorenzo Insigne and Mertens as the pair of strikers.
There is also faith in 22-year-old defender Sebastiano Luperto at left-back, resting Mario Rui.
Alex Meret, Faouzi Ghoulam, Vlad Chiriches and Amin Younes are long-term absentees.
Torino must do without Cristian Ansaldi, Iago Falque and Lorenzo De Silvestri, so Coach Walter Mazzarri launches Zaza with Belotti from the start for the first time.
Alex Berenguer and Chelsea-owned Ola Aina take the wing-back roles in Mazzarri’s usual 3-5-2.
Torino: Sirigu; Izzo, Nkoulou, Moretti; Aina, Meité, Rincon, Baselli, Berenguer; Zaza, Belotti
Torino bench: Ichazo, Rosati, Bremer, Djidji, Lukic, Soriano, Parigini, Damascan, Edera
Napoli: Ospina; Hysaj, Albiol, Koulibaly, Luperto; Callejon, Rog, Hamsik, Verdi; Insigne, Mertens
Napoli bench: Karnezis, D’Andrea, Maksimovic, Malcuit, Mario Rui, Fabian, Allan, Diawara, Zielinski, Milik