Napoli look to Victor Osimhen and Lorenzo Insigne, but have to revamp their defence against a Spezia side who beat them earlier this season.
It kicks off at the Stadio Alberto Picco at 14.00 UK time (13.00 GMT).
You can follow all the action as it happens from today’s four Serie A games on the LIVEBLOG.
That includes Udinese-Bologna, which also kicks off at 14.00 UK.
Napoli look to Victor Osimhen and Lorenzo Insigne, but have to revamp their defence against a Spezia side who beat them earlier this season.
It kicks off at the Stadio Alberto Picco at 14.00 UK time (13.00 GMT).
You can follow all the action as it happens from today’s four Serie A games on the LIVEBLOG.
That includes Udinese-Bologna, which also kicks off at 14.00 UK.
Spezia are just three points clear of the drop zone and have a very tough run-in, while Napoli already dropped points against Cagliari last week in stoppages and don’t want to make the same mistake here.
The Partenopei are in fifth place with 67 points, two behind Atalanta, Juventus and Milan.
Kalidou Koulibaly joins David Ospina, Stanislav Lobotka and Faouzi Ghoulam on the treatment table, while Nikola Maksimovic has COVID-19, so there have to be changes in defence.
Osimhen again gets the nod rather than Dries Mertens upfront, with support from Insigne, Matteo Politano and Piotr Zielinski.
Spezia have top scorer M’Bala Nzola suspended, with Leo Sena and Federico Mattiello injured.
Kevin Agudelo gets the nod as a False 9, flanked by Daniele Verde and Emmanuel Gyasi, rather than centre-forward Roberto Piccoli.
They already caused a shock when beating Napoli at the Stadio Maradona in January, and Vincenzo Italiano has been suggested as one of the possible heirs to Gennaro Gattuso on the Napoli bench.
Spezia: Provedel; Vignali, Chabot, Ismajli, Marchizza; Estevez, Ricci, Maggiore; Verde, Agudelo, Gyasi
Napoli: Meret; Di Lorenzo, Manolas, Rrahmani, Hysaj; Fabian Ruiz, Demme; Politano, Zielinski, L Insigne; Osimhen
Ref: Irrati