Leaders Juventus visit bottom of the table SPAL with a revamped XI due to injuries, suspension and the Champions League, giving Giorgio Chiellini his first start since August.
It kicks off at the Stadio Paolo Mazza in Ferrara at 17.00 GMT.
You can follow the build-up and action as it happens from this game, Bologna–Udinese and Fiorentina–Milan on the LIVEBLOG.
Leaders Juventus visit bottom of the table SPAL with a revamped XI due to injuries, suspension and the Champions League, giving Giorgio Chiellini his first start since August.
It kicks off at the Stadio Paolo Mazza in Ferrara at 17.00 GMT.
This is a top to tail battle, as SPAL are propping up the table with just 15 points compared to leaders Juventus on 57.
Gigi Di Biagio was brought in to replace sacked Leonardo Semplici, but lost his debut 2-1 to Lecce, the team’s fourth consecutive defeat.
He has entirely scrapped Semplici’s tactics for a 4-3-3 formation with Mattia Valoti and Gabriel Strefezza flanking Andrea Petagna.
Lucas Castro and Maurizio Sarri’s old Empoli and Napoli midfielder Mirko Valdifiori pull the strings, but Bryan Dabo and Alberto Cerri are injured.
Juventus make several changes, especially with the Champions League Round of 16 against Olympique Lyonnais coming up, but cannot afford to make mistakes with Lazio only one point behind them.
Leonardo Bonucci is suspended, with Miralem Pjanic, Gonzalo Higuain, Douglas Costa, Sami Khedira and Merih Demiral injured.
Cristiano Ronaldo was rested last week, so he returns eager to match the all-time record of 11 consecutive Serie A games on target, set by Gabriel Batistuta at Fiorentina and Fabio Quagliarella with Sampdoria.
It also marks the Portuguese legend’s 1,000th competitive match.
He is joined by Paulo Dybala and Juan Cuadrado in the trident attack, with Aaron Ramsey and Rodrigo Bentancur in midfield.
The big news is Chiellini’s first start since he tore his anterior cruciate ligament in August, having returned as a late substitute in last week’s 2-0 win over Brescia.
Juventus have a surprisingly poor recent record away to SPAL, losing here 2-1 in April 2019 and drawing 0-0 in March 2018.
SPAL: Berisha; Cionek, Bonifazi, Zukanovic, Reca; Missiroli, Valdifiori, Castro; Valoti, Petagna, Strefezza
SPAL bench: Thiam, Letica, Floccari, Murgia, Dabo, Vicari, Sala, Felipe, Di Francesco, Tomovic, Fares, Tunjov
Juventus: Szczesny; Danilo, Rugani, Chiellini, Alex Sandro; Ramsey, Bentancur, Matuidi; Cuadrado, Dybala, Ronaldo
Juventus bench: Buffon, Pinsoglio, De Sciglio, De Ligt, Coccolo, Wesley, Rabiot, Peeters, Bernardeschi, Olivieri
Ref: La Penna