Roma look to Borja Mayoral, Pedro and Carles Perez in the trip to Shakhtar Donetsk, with a 3-0 first leg lead to protect.
The second leg of the Europa League Round of 16 kicks off at 17.55 GMT.
You can follow all the build-up and action as it happens from this game and Milan-Manchester United on the LIVEBLOG.
Roma look to Borja Mayoral, Pedro and Carles Perez in the trip to Shakhtar Donetsk, with a 3-0 first leg lead to protect.
The second leg of the Europa League Round of 16 kicks off at 17.55 GMT.
Paulo Fonseca returns to Kiev against his old club and has a 3-0 first leg lead under his belt, but Shakhtar are not to be taken for granted.
They dropped into this competition from the Champions League, having beaten Real Madrid and finished ahead of Inter in their group.
Henrikh Mkhitaryan, Jordan Veretout, Nicolò Zaniolo and Chris Smalling are out of action, while Fonseca also has an eye on Sunday’s Serie A showdown with Napoli.
Borja Mayoral gets the nod upfront rather than Edin Dzeko, with Pedro and Carles Perez in support.
Leonardo Spinazzola was expected to rest, but he again starts with Rick Karsdorp on the wings.
Shakhtar are missing Ismaily, Taras Stepanenko, Maksym Malyshev and COVID case Viktor Kornienko, so Mykola Matviyenko is moved over to left-back.
The Ukrainians were in the Europa League semi-final last season, where they also suffered against an Italian team, losing 5-0 to Inter.
This game was originally meant to have several thousand fans in the stadium, but a decision was made yesterday by the local authorities to play behind closed doors.
Shakhtar Donetsk: Trubin; Dodo, Vitao, Kryvtsov, Matviyenko; Alan Patrick, Marcos Antonio, Maycon; Tete, Junior Moraes, Solomon
Shakhtar bench: Shevchenko, Pyatov, Khocholava, Taison, Dentinho, Marlos, Marquinhos, Bolbat, Sudakov, Konoplyanka, Bondar, Fernando
Roma: Pau Lopez; Ibanez, Cristante, Kumbulla; Karsdorp, Diawara, Villar, Spinazzola; Carles Perez, Pedro; Mayoral
Roma bench: Mirante, Fuzato, Pellegrini, Dzeko, Santon, Mancini, Bruno Peres, Calafiori, El Shaarawy
Ref: Lahoz (ESP)