Gennaro Gattuso lost his debut on the Napoli bench and is now forced to revamp his defence for a trip to Sassuolo, who lose Domenico Berardi.
It kicks off at the Mapei Stadium at 19.45 GMT.
You can follow all the action as it happens on the LIVEBLOG.
The Partenopei sensationally sacked Carlo Ancelotti, but have not improved in his absence, as Gattuso lost his debut 2-1 at home to Parma.
Gennaro Gattuso lost his debut on the Napoli bench and is now forced to revamp his defence for a trip to Sassuolo, who lose Domenico Berardi.
It kicks off at the Mapei Stadium at 19.45 GMT.
You can follow all the action as it happens on the LIVEBLOG.
The Partenopei sensationally sacked Carlo Ancelotti, but have not improved in his absence, as Gattuso lost his debut 2-1 at home to Parma.
Kalidou Koulibaly went off injured in that game and is still out of action, along with Nikola Maksimovic, Faouzi Ghoulam, Lorenzo Tonelli and Kevin Malcuit.
Sebastiano Luperto therefore steps in to centre-back with Kostas Manolas.
Jose Callejon again completes the trident with Arkadiusz Milik and Lorenzo Insigne, benching Dries Mertens and Hirving Lozano.
Sassuolo are unbeaten in four and fresh from a rescheduled midweek 2-0 victory away to Brescia.
There had been doubts about Berardi after a knock in training, and he is not even on the bench this evening.
Jeremie Boga is joined by Alfred Duncan and Junior Hamed Traore in support of Francesco Caputo.
Jeremy Toljan is suspended, so Mert Muldur steps in at right-back.
Gregoire Defrel, Vlad Chiriches and Andrea Consigli are still out injured.
Sassuolo: Pegolo; Muldur, Marlon, Peluso, Kyriakopoulos; Obiang, Locatelli; Duncan, Traore, Boga; Caputo
Napoli: Meret; Di Lorenzo, Manolas, Luperto, Mario Rui; Fabian Ruiz, Allan, Zielinski; Callejon, Milik, Insigne