Lautaro Martinez and Romelu Lukaku see Inter aim to get back on track by ending their traditionally poor record against Domenico Berardi’s Sassuolo.
It kicks off at the Mapei Stadium at 11.30 UK time (10.30 GMT).
Lautaro Martinez and Romelu Lukaku see Inter aim to get back on track by ending their traditionally poor record against Domenico Berardi’s Sassuolo.
It kicks off at the Mapei Stadium at 11.30 UK time (10.30 GMT).
There will be a minute’s silence in Reggio-Emilia, as this is the first match played since Sassuolo patron Giorgio Squinzi passed away.
The Neroverdi have not played for three weeks, as their game with Brescia was postponed as a mark of respect, followed then by a break for international duty.
There is a lengthy injury list for Roberto De Zerbi, who misses Rogerio, Medhi Bourabia, Giangiacomo Ferrari, Vlad Chiriches and Luca Mazzitelli.
Domenico Berardi and Francesco Caputo lead the attack, with support from Hamed Junior Traore, sending Gregoire Defrel to the bench.
Italy Under-21 international Alessandro Tripaldelli is surprisingly given the nod at right-back rather than Jeremy Toljan.
Inter lost Alexis Sanchez for three months following ankle surgery, with Danilo D’Ambrosio and Stefano Sensi also out of action this weekend.
With a crunch Champions League tie against Borussia Dortmund coming up, Conte is left with few real alternatives for squad rotation.
The pressure is on after their 2-1 defeat to Juventus saw their 100 per cent record and Serie A leadership disappear.
Lautaro Martinez is picked rather than Matteo Politano to partner Lukaku, but Diego Godin, Kwadwo Asamoah and Matias Vecino are rested in favour of Alessandro Bastoni, Cristiano Biraghi and Roberto Gagliardini.
Inter have really struggled against Sassuolo in recent years, managing only one point from their last five meetings.
Sassuolo: Consigli; Tripaldelli, Marlon, Peluso, Muldur; Obiang, Magnanelli, Duncan; Traore; Berardi, Caputo
Sassuolo bench: Turati, Russo, Boga, Djuricic, Defrel, Raspadori, Romagna, Toljan, Piccinini, Ghion, Locatelli, Kyriakopoulos
Inter: Handanovic; Skriniar, De Vrij, Bastoni; Candreva, Gagliardini, Brozovic, Barella, Biraghi; Lautaro Martinez, R Lukaku
Inter bench: Padelli, Berni, Godin, Ranocchia, Dimarco, Vecino, Asamoah, Lazaro, Borja Valero, Politano, Esposito
Ref: Giacomelli