Sassuolo welcome back Domenico Berardi but are weakened in defence as they host struggling Cesena.
It kicks off at 17.00 GMT, click here for a match preview.
The Neroverdi saw their all-time club record seven-round unbeaten run come to an end last week with defeat at Palermo, sealed in the final seconds.
Eusebio Di Francesco is determined to get them back on track going into 2015 and this is the perfect opportunity for them to ratchet up more points.
Sassuolo welcome back Domenico Berardi but are weakened in defence as they host struggling Cesena.
It kicks off at 17.00 GMT, click here for a match preview.
The Neroverdi saw their all-time club record seven-round unbeaten run come to an end last week with defeat at Palermo, sealed in the final seconds.
Eusebio Di Francesco is determined to get them back on track going into 2015 and this is the perfect opportunity for them to ratchet up more points.
Cesena are without a victory since the opening weekend and sacked Coach Pierpaolo Bisoli, so new boss Mimmo Di Carlo debuted with a 4-1 home defeat to Fiorentina.
Luigi Giorgi returns from suspension to bolster the Sea Horses, but they are still without Guido Marilungo, Francesco Renzetti, Gabriele Perico and Milan Djuric.
Hugo Almeida is again supported by Gregoire Defrel in a 3-5-1-1 system.
Di Francesco is very happy to have Italy Under-21 international Berardi back from a ban to complete the trident with Simone Zaza and Antonio Floro Flores, dropping Nicola Sansone.
However, Andrea Consigli and Paolo Cannavaro are suspended, so Alberto Pomini goes in goal.
Gianluca Pegolo and Thomas Manfredini remain on the treatment table.
Sassuolo: Pomini; Vrsaljko, Terranova, Acerbi, Peluso; Taider, Magnanelli, Missiroli; Berardi, Zaza, Floro Flores
Sassuolo bench: Polito, Celeste; Antei, Bianco, Gazzola, Longhi, Brighi, Biondini, Chibsah, Pavoletti, Sansone, Floccari
Cesena: Leali; Magnusson, Lucchini, Capelli; Giorgi, Carbonero, Cascione, Ze Eduardo, Mazzotta; Defrel, Almeida
Cesena bench: Agliardi, Bressan; Krajnc, Coppola, Nica, Valzania, De Feudis, Pulzetti, Rodriguez, Brienza, Succi, Garritano