Claudio Ranieri makes his debut on the Sampdoria bench against old club Roma, with Andrea Bertolacci and Nikola Kalinic starting.
It kicks off at 14.00 UK time (13.00 GMT), as weather warnings seem to have been relaxed.
You can follow the build-up and action as it happens from all six Serie A games on the LIVEBLOG.
This is the first match in charge for Ranieri, as Eusebio Di Francesco was fired following six defeats in seven Serie A games.
Claudio Ranieri makes his debut on the Sampdoria bench against old club Roma, with Andrea Bertolacci and Nikola Kalinic starting.
It kicks off at 14.00 UK time (13.00 GMT), as weather warnings seem to have been relaxed.
You can follow the build-up and action as it happens from all six Serie A games on the LIVEBLOG.
This is the first match in charge for Ranieri, as Eusebio Di Francesco was fired following six defeats in seven Serie A games.
Curiously, Ranieri had also replaced the same Coach at Roma back in March and now makes his debut facing his beloved hometown club.
To add a further twist of fate, today is also Ranieri’s 68th birthday.
Karol Linetty is injured, but Ranieri changes the tactics to a 4-3-1-2 formation with Emiliano Rigoni rather than Gaston Ramirez supporting Manolo Gabbiadini and Fabio Quagliarella.
Albin Ekdal was expected to step into midfield, but in a shock twist, Ranieri gives Bertolacci a debut from the start.
Bertolacci only signed on for Samp as a free agent on October 8, as he was out of contract with Milan and has not played for since a 5-2 Europa League win over Dudelange on November 29, 2018.
Roma have a lengthy absentee list, missing Edin Dzeko (who is not risked with a protective face mask after surgery on a facial fracture two weeks ago), Lorenzo Pellegrini, Davide Zappacosta, Cengiz Under, Henrikh Mkhitaryan and Amadou Diawara.
Alessandro Florenzi returns after a virus that saw him lose a couple of kgs and miss out on international duty, but he is moved to a wide left role in the supporting trident with Nicolò Zaniolo and Justin Kluivert.
Kalinic is the only real remaining option as centre-forward, hoping for better after his last-gasp goal was disallowed against Cagliari.
Because of that incident and the consequent protests, Roma Coach Paulo Fonseca is suspended and sits in the stands.
Sampdoria: Audero; Bereszynski, Murillo, Colley, Murru; Vieira, Bertolacci, Jankto; Rigoni; Gabbiadini, Quagliarella
Roma: Pau Lopez; Spinazzola, Mancini, Smalling, Kolarov; Veretout, Cristante; Kluivert, Zaniolo, Florenzi; Kalinic